Narcotic painkillers increase the pain, say scientists.

"We have for the first time able to show that even short-term use of opioids leads to long-term and extremely negative effects on the perception of pain We have found that the very therapy is one of the causes of chronic pain epidemic in the United States today." - Peter Grace said (Peter Grace) from University of Colorado at Boulder (USA).In recent years, among the US population, especially of European origin, avalanche manner growing epidemic of chronic pain. According to estimates by Nora Volkov (Nora Volkow), director of the National Institute on Drug Dependence United States, today approximately 30% of the population suffers from neuropathic pain.

Due to uncleanliness of pharmaceutical companies and the connivance of authorities, in the US today the primary means to deal with such pain are narcotic drugs - OxyContin, Vicodin and other semi-synthetic analogs of morphine. Thanks to them, the number of deaths from overdose of painkillers tripled in the last 10 years, while the number of people with chronic pain continues to grow.Grace and his colleagues have uncovered a possible secret of why people for decades can not refuse to accept the drug painkillers, watching the changes that occur in the body of rats with the appearance of foci of chronic pain.

They managed to find a curious effect that caused opioid painkillers. It turned out after repeated use, they are extremely unusual effect on the behavior of the so-called glial cells surrounding the nerves in the spinal cord and brain. Normally, these cells as explained scientists protect the nervous system from damage or "intruders", but their role changes with the development of chronic pain.

For the second receiving anesthetic involves an unusual program behavior in glial cells that cause inflammation at the point where the nerve was damaged. As a result of the pain, if not to block opioid, not only dull, but also increases and becomes chronic really 5-6 day receiving drug painkillers.

Experiments have shown that this unusual side effect can be suppressed by blocking the work of two genes - TLR4 and P2X7R - in the glial cells of the spinal cord. As scientists hope further study of the data sections of DNA cause inflammation when taking opioids, will help you understand how to make pain relievers safer for human health.

"The consequences of this discovery is extremely high for all people taking drugs such as morphine, oxycodone or methadone, as we now know that even a short-term taking them increases pain and makes it more durable. This ugly side of painkillers yet we have not been" - concludes Linda Watkins (Linda Watkins), Grace's colleague and co-author of the article.